Best Hematologists for Severe Combined Immunodeficiency in Delhi NCR, India
This page lists 10 severe combined immunodeficiency doctors in Delhi NCR, India. Review each doctor's experience, specialty and hospital, then contact our care team for help with the next step.
Quick answer
This page lists 10 severe combined immunodeficiency doctors in Delhi NCR, India. Review each doctor's experience, specialty and hospital, then contact our care team for help with the next step.
About Severe Combined Immunodeficiency doctors in Delhi NCR, India
This directory is based on doctors currently listed in GAF Healthcare's registry. Clinical suitability varies by patient; a doctor should review your history and investigations before any treatment decision.
About the Condition
What is Severe Combined Immunodeficiency?
Severe Combined Immunodeficiency (SCID) is a rare but life-threatening inherited disorder in which the immune system is profoundly impaired, leaving the body almost entirely unable to fight off bacterial, viral, or fungal infections. Without early intervention, affected infants typically experience recurrent, severe, and often opportunistic infections that can become fatal within the first year or two of life. Associated complications include failure to thrive, chronic lung damage from repeated respiratory infections, and serious reactions to live-attenuated vaccines or blood transfusions containing viable lymphocytes. A qualified clinician will take a detailed family and medical history alongside specific laboratory investigations to assess the nature and extent of immune impairment before any treatment pathway is discussed.
Individual assessmentEvery case is different
Complete evaluationUnderstand the condition first
Specialist reviewChoose the right approach
Medical assessment helps clarify severity and identify appropriate options.
Treatment options for Severe Combined Immunodeficiency
Care may include lifestyle changes, medical treatment, specialist review or a procedure, depending on the diagnosis, associated conditions and individual goals. The options below are associated with this condition in the GAF Healthcare directory.
Allogeneic Bone Marrow Transplant involves replacing a patient's diseased or malfunctioning bone marrow with healthy blood-forming stem cells from a matched donor.
Why it may be consideredIt is a curative treatment option for conditions like Sickle Cell Disease and Severe Combined Immunodeficiency (SCID), aiming to restore normal blood cell and immune function. India offers this complex procedure at leading transplant centers with internationally trained hematologists at a fraction of Western costs.
NABH — National Accreditation Board for Hospitals & Healthcare Providers accreditationNABL — National Accreditation Board for Testing and Calibration Laboratories accreditation
NABH — National Accreditation Board for Hospitals & Healthcare Providers accreditationNABL — National Accreditation Board for Testing and Calibration Laboratories accreditation
Many international patients consider India for severe combined immunodeficiency treatment for several reasons, including:
More affordable estimates
Competitive indicative costs compared with many other countries, for similar clinical standards.
Internationally accredited hospitals
Hospitals experienced in treating international patients.
Experienced specialists
Doctors who regularly manage similar cases.
Care coordination support
A team to help with planning, medical translation and follow-up.
How this directory is built
Doctors are matched using the specialty, location, condition (Severe Combined Immunodeficiency) recorded in their profiles. Inclusion is not an endorsement and does not guarantee a treatment outcome.
Need help with the next step?
Share your needs with our care coordination team for information about doctors and hospitals.
Common questions
FAQs about Severe Combined Immunodeficiency in Delhi NCR, India
What is Severe Combined Immunodeficiency?
Severe Combined Immunodeficiency (SCID) is a group of rare genetic disorders characterized by severely reduced or absent T-cell function—often accompanied by B-cell and natural killer (NK) cell deficits—that together eliminate the body's ability to mount an effective immune response against infections.
What are the symptoms and health risks of Severe Combined Immunodeficiency?
Infants with SCID commonly present with recurrent pneumonias, persistent oral thrush or skin candidiasis, chronic diarrhea, poor weight gain, and unusually prolonged or severe infections caused by organisms that would not normally trouble a healthy immune system. Some children appear well at birth for the first weeks of life due to residual maternal antibodies, which can delay recognition of the condition. These signs and symptoms are suggestive but are not sufficient on their own to establish a diagnosis—formal immunological testing is required.
How is Severe Combined Immunodeficiency diagnosed?
Diagnosis is typically confirmed through a combination of a complete blood count (which often reveals profound lymphopenia), flow cytometry to quantify T, B, and NK cell subsets, and functional assays measuring lymphocyte proliferative response to mitogens. Newborn screening programs in many countries now include T-cell receptor excision circle (TREC) assays on dried blood spots, enabling detection before symptoms develop. Genetic testing to identify the specific causative mutation—among more than twenty known gene variants, including defects in IL2RG, ADA, RAG1, and RAG2—is important for determining the precise subtype, guiding treatment planning, and informing family counseling; all findings are interpreted by a clinician with expertise in primary immunodeficiency.
How is Severe Combined Immunodeficiency treated?
The treatment approach depends on the specific SCID subtype, the child's clinical condition, and the availability of a suitable donor, but curative intent almost always involves hematopoietic stem cell transplantation—most commonly allogeneic bone marrow transplant (BMT). Outcomes are significantly better when transplantation is performed before serious infections establish, ideally in the first months of life, which underlines the importance of early diagnosis through newborn screening. For the adenosine deaminase (ADA-SCID) subtype specifically, enzyme replacement therapy and, in eligible patients, gene therapy represent additional curative or bridging options that a specialist team will evaluate on an individual basis.
Can Severe Combined Immunodeficiency be treated without surgery?
While SCID has no meaningful long-term non-procedural cure, supportive and bridging measures are used to keep affected infants as safe as possible pending definitive treatment: these include protective isolation, prophylactic antimicrobial and antifungal medications, intravenous immunoglobulin (IVIG) replacement to partially compensate for absent antibody production, and—for ADA-SCID—enzyme replacement therapy (ERT) as a bridge to transplant or gene therapy. These measures reduce infection risk but do not correct the underlying immune defect, and the decision to use them, and for how long, is made by the treating clinical team based on each child's individual circumstances.
When is Allogeneic Bone Marrow Transplant considered for Severe Combined Immunodeficiency?
Allogeneic Bone Marrow Transplant may be considered when conservative or medical options have not achieved enough improvement, or when the severity of the condition warrants it. The decision depends on clinical assessment, expected benefits and individual risks.
Which doctor treats Severe Combined Immunodeficiency?
SCID is evaluated and managed by a clinical immunologist or pediatric immunologist with subspecialty expertise in primary immunodeficiency diseases, working closely with a hematologist and bone marrow transplant (BMT) specialist who has experience in pediatric allogeneic transplantation. Depending on the treatment centre, infectious disease specialists, pulmonologists, and clinical geneticists are also typically involved in the multidisciplinary team.
How do I choose a doctor for Severe Combined Immunodeficiency?
When comparing care options, it is worth asking about a centre's volume of pediatric allogeneic bone marrow transplants specifically for primary immunodeficiency, their newborn-to-transplant timeline data, access to matched unrelated donor registries, and the availability of an integrated multidisciplinary team covering immunology, transplant medicine, infectious disease, and long-term follow-up. Post-transplant monitoring for immune reconstitution and graft function is an ongoing commitment, so understanding a centre's follow-up protocol before making a decision is equally important.
What documents do international patients need to share for a medical evaluation?
Share a medical summary, investigation and imaging or biopsy reports where relevant, a current medication list, previous diagnoses and related treatment records. Provide clear copies with translation where needed.
How does GAF Healthcare help international patients plan treatment in India?
Our care coordination team helps review initial medical information, connect you with suitable doctors and hospitals, explain next steps and indicative estimates, and organise a treatment plan before travel.
