This page lists the liver transplant & hpb hospitals in our directory offering Alpha-1-Antitrypsin Deficiency in Chennai, India, including Apollo Hospitals, Greams Road, Gleneagles Global Hospital, Dr. Rela Institute and Medical Centre, SIMS Hospital and others. Each listing links through to the hospital's full profile page.
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Top Hospitals for Alpha-1-Antitrypsin Deficiency in Chennai, India
🇮🇳 Apollo Hospitals, Greams Road
Patients considering alpha-1-antitrypsin deficiency can be cared for by Apollo Hospitals, Greams Road's care team in Chennai, India, from initial consultation through recovery. Apollo Hospitals, Greams Road, accredited by JCI, NABH, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 Gleneagles Global Hospital
Patients considering alpha-1-antitrypsin deficiency can be cared for by Gleneagles Global Hospital's care team in Chennai, India, from initial consultation through recovery. Gleneagles Global Hospital, accredited by NABH, JCI, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 Dr. Rela Institute and Medical Centre
Patients considering alpha-1-antitrypsin deficiency can be cared for by Dr. Rela Institute and Medical Centre's care team in Chennai, India, from initial consultation through recovery. Dr. Rela Institute and Medical Centre, accredited by NABH, NABL, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 SIMS Hospital
Patients considering alpha-1-antitrypsin deficiency can be cared for by SIMS Hospital's care team in Chennai, India, from initial consultation through recovery. SIMS Hospital, accredited by NABH, JCI, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 Sankara Nethralaya
Patients considering alpha-1-antitrypsin deficiency can be cared for by Sankara Nethralaya's care team in Nungambakkam, Chennai, India, from initial consultation through recovery. Sankara Nethralaya, accredited by NABH, NABL, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 Apollo First Med Hospitals, Kilpauk
Patients considering alpha-1-antitrypsin deficiency can be cared for by Apollo First Med Hospitals, Kilpauk's care team in Kilpauk, Chennai, India, from initial consultation through recovery. Apollo First Med Hospitals, Kilpauk, accredited by NABH, JCI, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 MIOT International
Patients considering alpha-1-antitrypsin deficiency can be cared for by MIOT International's care team in Manapakkam, Chennai, India, from initial consultation through recovery. MIOT International, accredited by NABH, NABL, JCI, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
🇮🇳 MGM Healthcare
Patients considering alpha-1-antitrypsin deficiency can be cared for by MGM Healthcare's care team in Chennai, India, from initial consultation through recovery. MGM Healthcare, accredited by NABH, JCI, follows recognised patient-safety and quality-of-care standards when performing alpha-1-antitrypsin deficiency.
Top Liver Transplant & HPB Doctors in Chennai, India
FeaturedDr. Arul Kumar S
- 18+ years of experience in Hepato-Pancreato-Biliary (HPB) Surgeon
- Associate Consultant, Department of Surgical Gastroenterology and HPB Surgery, Rela Hospital, Chennai
- Training in HPB Surgery, Christian Medical College, Vellore
- Live donor liver transplantation
- Deceased donor liver transplant
- Hilar cholangiocarcinoma resection
- Whipple procedure (pancreaticoduodenectomy)
- Complex liver resections
Dr. Dinesh Jothimani
- 19+ years of experience in Hepatologist
- Director, Hepatology, Gastroenterology & Hepatobiliary — Dr. Rela Institute & Medical Centre, Chennai
- Consultant Hepatologist and Liver Transplant Physician — Global Hospitals, Chennai
- ERCP (Endoscopic Retrograde Cholangiopancreatography)
- Liver Transplant Assessment and Management
- Hepatic Biopsy and Fibroscan
- Endoscopic Variceal Ligation
- Management of Acute Liver Failure
Dr. Gomathy Narasimhan
- 20+ years of experience in Liver Transplant Surgeon
- Senior Consultant — Liver and Renal Transplant Surgery & Surgical Gastroenterology, Rela Hospital, Chennai, Present
- ASTS Fellowship in Transplant Surgery, Baylor University Medical Center, Dallas, Texas, USA, 2006
- Adult liver transplantation
- Pediatric liver transplant
- Living donor kidney transplant
- Combined liver-kidney transplant
- Multivisceral transplant
Dr. Jasper Sandeep Rajasekar
- 11+ years of experience in Hepatobiliary & Liver Transplant Surgeon
- Associate Consultant, Surgical Gastroenterology, Rela Hospital, Chennai — Present
- Liver Transplantation Unit Member, Rela Hospital, Chennai — 2016–Present
- Living donor liver transplantation (LDLT)
- Deceased donor liver transplantation
- Pediatric liver transplantation
- Hepatocellular carcinoma resection
- Whipple procedure (pancreaticoduodenectomy)
Dr. Joy Varghese
- 25+ years of experience in Hepatologist & Liver Transplant Physician
- Director of Hepatology & Transplant Hepatology – Gleneagles HealthCity, Chennai, India – Present
- Program Director, Liver Transplant Society of India (LTSI) Fellowship in Transplant Hepatology – Gleneagles HealthCity, Chennai – Present
- Orthotopic Liver Transplantation
- Living Donor Liver Transplantation
- Liver Biopsy
- Endoscopic Variceal Ligation
- Therapeutic Plasma Exchange for Liver Diseases
Dr. Kumar Palaniappan
- 20+ years of experience in Hepatobiliary & Liver Transplant Surgeon
- Clinical Lead – Laparoscopy Liver Surgery, Senior Consultant Abdominal Trauma, HPB Surgery & Liver Transplantation, Rela Hospital, Chennai – Present
- Senior Consultant Hepatobiliary & Liver Transplant Surgery, Gleneagles Global Hospitals, Chennai
- Liver Transplantation (Living & Deceased Donor)
- Laparoscopic Liver Resection
- Hepatic Tumor Surgery
- Whipple Procedure (Pancreaticoduodenectomy)
- Gastrectomy
How we selected these hospitals
A hospital appears on this page when Liver Transplant & HPB is among its listed specialties and it is located in Chennai, India. Hospitals are not ranked by a proprietary "best" score — the order follows the listed rating (highest first), the same field shown on each hospital's profile.
How to Select the Best Hospital for Alpha-1-Antitrypsin Deficiency in Chennai, India?
Choosing the right hospital for alpha-1-antitrypsin deficiency is one of the most important decisions in your treatment journey. A few factors are worth weighing before you decide:
International Accreditation
Look for a hospital with international accreditation such as JCI or NABH — see the accreditation badges shown for each hospital below.
Specialization
Check that the hospital's listed specialties actually include liver transplant & hpb rather than only general care.
Capacity and Track Record
Bed count and year established (shown below for each hospital) are a reasonable proxy for scale and operating experience.
Transparent Costs
Ask for an itemised, all-inclusive estimate — hospital charges, room category and stay — before you travel. Our cost calculator (linked below) gives a starting estimate.
Understanding Alpha-1-Antitrypsin Deficiency
Alpha-1-Antitrypsin Deficiency (AATD) is a serious inherited metabolic disorder that leads to progressive emphysema and liver disease; AAT augmentation therapy (intravenous infusion of purified human alpha-1-antitrypsin) is the only disease-modifying treatment proven to slow lung function decline in Pi*ZZ and related phenotypes, with clinical studies demonstrating a statistically significant reduction in CT-measured lung density loss and annual FEV1 decline.
Clinical Overview
- Alpha-1-Antitrypsin Deficiency (AATD) is an autosomal co-dominant genetic disorder caused by mutations in the SERPINA1 gene, most commonly the Pi*Z (Glu342Lys) allele.
- The resulting misfolded AAT protein is retained within hepatic endoplasmic reticulum, reducing circulating AAT to less than 11 µmol/L — far below the protective threshold of 35 µmol/L needed to neutralise neutrophil elastase in alveolar tissue.
- The unopposed elastase activity progressively destroys alveolar walls, producing panlobular emphysema with a characteristic basal predominance on high-resolution CT (HRCT).
Who is a Candidate?
- CONFIRMED PHENOTYPE: Pi*ZZ, Pi*ZNull, Pi*SZ, or other severe AATD genotypes confirmed by serum AAT level (< 11 µmol/L or < 57 mg/dL by nephelometry) AND SERPINA1 genotyping or isoelectric focusing (IEF)
- PULMONARY ELIGIBILITY FOR AUGMENTATION: FEV1 15–65% predicted on spirometry; CT-documented emphysema (quantitative PD15 densitometry); non-smoker or smoking cessation confirmed ≥ 6 months; absence of IgA deficiency (risk of anaphylaxis to plasma products)
- LIVER DISEASE EVALUATION: All AATD patients require baseline liver assessment — serum LFTs, FibroScan® (liver stiffness ≥ 7 kPa warrants enhanced surveillance), abdominal ultrasound, and AFP for HCC screening in cirrhotic patients
- REQUIRED PRE-TREATMENT DIAGNOSTICS: Full pulmonary function tests (spirometry, body plethysmography, DLCO); HRCT thorax with quantitative densitometry; 6-minute walk test (6MWT) and SGRQ-C quality-of-life score; echocardiography (ECHO) to exclude pulmonary hypertension (RVSP > 40 mmHg modifies transplant candidacy); complete blood count, coagulation profile, serum protein electrophoresis; hepatitis B/C serology and HIV screening
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Treatment Options & Approaches
- STANDARD AAT AUGMENTATION THERAPY (INTRAVENOUS): Weekly IV infusion of purified, pasteurised, human plasma-derived alpha-1-antitrypsin concentrate at 60 mg/kg body weight, administered over 15–30 minutes in an outpatient or day-care setting.
- This is the only FDA-approved, EMA-approved disease-modifying therapy for AATD-related emphysema.
- The RAPID and RAPID-OLE trials (the only double-blind, placebo-controlled studies in AATD) demonstrated a 34% reduction in annual CT lung density loss (PD15 endpoint) and a significant benefit in FEV1 decline in the treatment arm over 4 years.
Recovery
- PHASE 1 — PRE-ARRIVAL PREPARATION (2–4 weeks before travel):
Risks to be aware of
- AAT augmentation therapy has an established safety profile across three decades of clinical use, but patients and clinicians must consider the following specific risks and limitations:
Why GAF Healthcare
- GAF Healthcare provides a fully integrated non-medical support infrastructure designed to eliminate barriers to international treatment access for AATD patients:
Common questions about Alpha-1-Antitrypsin Deficiency
What is the cost of Alpha-1-Antitrypsin Deficiency Treatment (AAT Augmentation Therapy) in India versus the UAE?
How long do I need to stay in India or the UAE before I am fit to fly home after starting AAT Augmentation Therapy?
What is the success rate of AAT Augmentation Therapy and related AATD treatments?
Related pages
How GAF Healthcare Assists in Choosing the Best Hospital for Alpha-1-Antitrypsin Deficiency in Chennai, India
Discover the Top Hospitals for Alpha-1-Antitrypsin Deficiency in Chennai, India
This page lists 8 accredited liver transplant & hpb hospitals in Chennai, India, so you can compare accreditation, specialties and bed capacity in one place.
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Transparent, All-Inclusive Costs
We provide a single, itemised quote covering hospital charges and stay — no hidden fees, and there's no charge for requesting an estimate. Use our cost calculator alongside this page for a first estimate.
Visa, Travel and Stay Coordination
Once you choose a hospital, we help arrange the medical visa invitation letter, hotel or serviced-apartment booking nearby, airport pickup and transport to your appointments.
Curious what treatment might cost for your case? Use our cost calculator for a personalized estimate.
Patient Success Story
Frequently asked questions about alpha-1-antitrypsin deficiency in Chennai, India
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